It is the most wonderful time of the year! The hustle and bustle—shopping, wrapping, cooking, baking, and getting together with friends and family—what could be better? Yet for those living with mental health conditions, from depression to schizophrenia, this could feel like the hardest time of the year. Reflecting on the latest FDA announcements made me pause and ask, “How can we better support people facing mental health challenges during the holidays?”

In October 2003, the FDA warned that antidepressants may be associated with suicidality among individuals younger than 18 shortly after starting treatment. By January 2005, a permanent black box warning was required on product labels and advertisements for all antidepressant drugs. In May 2007, the FDA expanded this warning to include young adults up to age 24. Fast forward to 2024: an extensive literature review identified 34 studies on depression and suicide-related outcomes published after the warnings were issued. These findings, described as “very concerning” by Roger McIntyre, MD, professor of psychiatry and pharmacology at the University of Toronto, suggest it’s time to rethink and possibly recalibrate these warnings. The FDA stated it evaluates such studies as part of its ongoing mission to protect public health.

On a brighter note, the FDA has approved “Cobenfy,” the first antipsychotic drug for schizophrenia targeting cholinergic receptors rather than dopamine receptors, which have been the standard of care for decades. Schizophrenia, a serious mental health condition affecting around 2.8 million adults in the U.S., interferes with thinking, emotions, decision-making, and relationships. “This is possibly one of the most exciting developments in our field,” commented Dr. Sameer Jauhar, consultant psychiatrist at King’s College London.

As we celebrate this “happiest time of the year,” let’s remember those who might be struggling. Whether it’s a family member avoiding gatherings or even yourself, know that hope is out there. Share kindness and good wishes, and remember—you never know the personal battles someone else is facing.

Stay well and stay informed!