Findings of a study published in JAMA Network Open, suggest that there are distinct SARS-CoV-2 viral-specific antibody response profiles that vary based on age, with younger children exhibiting higher levels of IgG, total, and functional antibody activity than adolescents and young adults. These findings may partly explain the overall lower rate of symptoms and cases of severe disease in children infected with SARS-CoV-2.

The concern with these findings is that children with lower incidence of symptoms and decreased disease severity may represent an important role in viral transmission in the community. Increased screening of school-aged children, even those without overt symptoms or exposure, may be an important step in curbing the pandemic.

There has been a ton of discussion, disagreement, and overall fear regarding children and COVID-19. Given that the 2020-2021 school year resumed and approximately 56 million school-aged children and adolescents in the United States are participating in in-person and/or remote classes, it is critical that we better understand the SARS-CoV-2 viral-specific immune responses in children. Lots to think about, maybe a vaccine for this population is coming soon. Stay well, mask up and stay tuned!