Have you ever wondered if the medications we give our residents might be doing more harm than good over time? A few years back, we shared concerns about anticholinergic medications and physical decline—specifically how these drugs can cause short-term effects like confusion and memory loss in older adults by blocking acetylcholine in the nervous system.

Now, new research takes those concerns even further. A study published in JAMA Network Open followed more than 4,000 older adults for over eight years. It found that higher exposure to anticholinergic medications was linked to a faster deterioration in walking speed and grip strength. These may sound like small changes, but they can quickly interfere with daily living and independence.

So, which medications should raise concern? The 2023 AGS Beers Criteria® offers an updated list of medications considered potentially inappropriate for older adults. Common examples include Benadryl, Tylenol PM, many antidepressants, medications for incontinence, antipsychotics, and some antiepileptics.

Lead researcher Shelly Gray, PharmD, MS, noted the findings support avoiding these medications whenever possible. As highlighted in McKnight’s Long-Term Care News, reducing cumulative exposure is essential for preserving long-term physical ability. The study, published in JAMA Network Open, emphasized that even small, steady losses in performance can become clinically meaningful over time.

This new evidence adds weight to the growing concern about anticholinergic medications and physical decline, urging communities to evaluate current regimens. It’s a good moment to revisit prescriptions with attending physicians and pharmacy partners—especially those meds that may no longer be needed. Supporting our residents means staying vigilant about what helps and what hinders their well-being.

Stay well and stay informed!