A robust and responsive testing infrastructure is essential to our success in stopping the spread of SARS-CoV-2, the virus that causes COVID-19. This overview describes current information on the categories of tests used to detect SARS-CoV-2 infection and the intended strategies for use of those tests, including to diagnose infection, to screen in an effort to reduce asymptomatic or presymptomatic transmission, and to monitor trends in infection. This guidance also includes considerations for health equity in testing; choosing a test; interpretation of SARS-CoV-2 test results in vaccinated persons; links to guidance for specific settings (e.g., K-12 schools, businesses, non-healthcare workplaces, correctional and detention facilities); and other considerations when deciding to test. This information is intended for use by healthcare providers and public health professionals and those organizing and implementing testing in non-healthcare settings such as schools, workplaces, and congregate housing. Information for the general public on SARS-CoV-2 testing is also available. This guidance has been developed based on what is currently known about SARS-CoV-2 infection and COVID-19 and is subject to change as additional information becomes available.