Populations such as healthcare workers (HCW) that are unable to practice physical distancing are at high risk of acquiring Coronavirus disease-2019 (COVID-19). In these cases pharmacological prophylaxis would be a solution to reduce severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) transmission. Hydroxychloroquine has in vitro antiviral properties against SARS CoV-2. A recent study was sought to determine the efficacy and safety of hydroxychloroquine as prophylaxis for COVID-19.

Although pharmacologic prophylaxis is an attractive preventive strategy against COVID-19, the current body of evidence failed to show clinical benefit for prophylactic hydroxychloroquine and showed a higher risk of adverse events when compared to placebo or no prophylaxis. Most of us are in the position of doubting the efficacy of this medication from the information shared through the media over the past year. This study confirms what everyone was saying. Follow the CDC’s guidance on preventing the spread of infection, mask up, wash your hands, social distance and stay healthy!

Stay the course, stay well, mask up, get vaccinated, and stay tuned!