It might sound surprising, but have you heard the latest about nitrous oxide therapy for treatment-resistant depression? It turns out “laughing gas” might offer more than a moment of levity. It may actually help residents who are struggling with depression that hasn’t responded to other treatments.

Depression, also known as major depressive disorder or clinical depression, is a serious mood disorder. It affects how a person feels, thinks, and acts. And while it’s common among older adults, it’s not a normal part of aging. It requires real support. Counseling and medications help many people, but not all. For those living with treatment-resistant depression (TRD), options have been limited.

That’s why a recent clinical trial caught so much attention. In the study, just one 60-minute inhalation of nitrous oxide (N₂O) led to a significant improvement in depression symptoms within 24 hours. Two weeks later, those who received the gas had meaningfully lower depression scores compared to those who didn’t. The findings were summarized in the article ‘Laughing Gas’ a New Option for TRD in Older Adults?.

Paul Myles, MD, of the Alfred Hospital in Melbourne, explained, “I think there is enough evidence to support a consideration of nitrous oxide therapy in people who have failed at least two conventional treatments.” His comments, featured alongside the data in the full study published in JAMA Psychiatry, also emphasized the need for psychiatric supervision and caution around misuse.

Sounds a bit out there, doesn’t it? Still, if you’re caring for residents with long-standing depression, it might be worth a conversation with your Medical Director. Nitrous oxide therapy for treatment-resistant depression isn’t ready for everyday use in senior living communities, but it is being taken seriously in clinical circles. That alone is reason enough to stay curious. The graphic below offers a helpful snapshot of four key things to know about depression and older adults.

Stay well and stay informed!